2. Signaling Pathways
  3. PROTAC
  4. Ligands for Target Protein for PROTAC

Ligands for Target Protein for PROTAC

Target Protein-binding Moiety

Ligands for Target Protein for PROTAC

Related Products

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The PROTAC molecule consists of a target protein ligand and an E3 ubiquitin ligase ligand, with a linker binds them together. The ligand for target protein will lead to attachment of a PROTAC to the proteins of interest for ubiquitin and subsequent degradation.

Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases (such as MEK, KRAS, CDK and Bcr/Abl), transcription factors (such as p53, STAT, RAR, ER and AR), epigenetic tools (such as HDAC and BET bromodomain) and E3 ligase themselves (such as MDM2).

Ligands for Target Protein for PROTAC Related Products (510):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-174355
    HPK1 ligand 3
    HPK1 ligand 3 is a ligand for target protein for PROTAC that can be used to synthesize PROTAC HPK1 Degrader-4 (HY-174135).
    HPK1 ligand 3
  • HY-151476
    GID4 Ligand 2 3031442-90-4
    GID4 Ligand 2 (compound 67) is a selective GID4 binder (IC50=18.9 μM; Kd=17 μM). GID4 Ligand 2 can be used for the synthesis of PROTACs.
    GID4 Ligand 2
  • HY-181595
    TEAD ligand 5 2417720-74-0
    TEAD ligand 5 (Compound S19) is a TEAD PROTAC ligand. TEAD ligand 5 can be conjugated with E3 ligase Ligand (HY-181531) and linker (HY-181608) to synthesize PROTAC TEAD/IAP degrader-1 (HY-181594) .
    TEAD ligand 5
  • HY-169375
    RSL3-4-Me 3049087-33-1
    RSL3-4-Me is the active control of the target protein ligand Demethyl-RSL3 (HY-135832), which can be used for the synthesis of PROTAC .
    RSL3-4-Me
  • HY-161959
    EP300/CBP ligand 1
    EP300/CBP ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). EP300/CBP ligand 1 can be used for synthesis dCE-2 (HY-161958).
    EP300/CBP ligand 1
  • HY-175242
    PROTAC BRD4 ligand-4 2954925-72-3
    PROTAC BRD4 ligand-4 is a BRD4 ligand, which can be used to synthesize PROTAC BRD4 Degrader-37 (HY-175225).
    PROTAC BRD4 ligand-4
  • HY-168691
    PTPN2 ligand 1 3032975-34-8
    PTPN2 ligand 1 is a PROTAC target protein ligand (Ligands for Target Protein for PROTAC). PTPN2 ligand 1 can be used to synthesize PVD-06 (HY-149760).
    PTPN2 ligand 1
  • HY-168018
    Demethyl-NSC682769 3058483-40-9
    Demethyl-NSC682769 is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). Demethyl-NSC682769 can be used in synthesis PROTAC YAP degrader-1 (HY-168016).
    Demethyl-NSC682769
  • HY-175689
    PDEδ-IN-1 903157-37-9
    PDEδ-IN-1 is the ligand of PDEδ. PDEδ-IN-1 can be used to synthesize PDEδ autophagic degrader 1 (HY-157458).
    PDEδ-IN-1
  • HY-179158
    CHK1-IN-15
    CHK1-IN-15 (compound 9a) is a ATP-kompetitive inhibitor of Checkpoint-Kinase-1 (CHK1) with a 95% binding at 1.0 µM. CHK1-IN-15 is a Chk1 target protein ligand of MA203 (HY-179157). CHK1-IN-15 can be used in cancer-related research.
    CHK1-IN-15
  • HY-183441
    ALK5 ligand-1 3125240-66-3
    ALK5 ligand-1 (a31's ALK5 ligand) is a ligand of Anaplastic lymphoma kinase ALK5 with higher selectivity for ALK5 than for ALK4. ALK5 ligand-1 can be used to synthesize PROTAC degraders targeting ALK5. ALK5 PROTACs induce ALK5 degradation dependent on the ubiquitin-proteasome system and exert antifibrotic activity. ALK5 ligand-1 can be used in studies of pulmonary fibrosis.
    ALK5 ligand-1
  • HY-182933
    BTK ligand-20
    BTK ligand-20 (compound 1) is a BTK ligand. BTK ligand-20 serves as a target protein ligand for the synthesis of PROTAC BTK Degrader-15 (HY-182910). BTK ligand-20 is applicable to cancer research.
    BTK ligand-20
  • HY-168662
    Palbociclib-CH2COOH 2139329-57-8
    Palbociclib-CH2COOH is a Ligands for Target Protein for PROTACs. Palbociclib-CH2COOH can serve as an active control for the target protein ligand of CPD-39 (HY-168664) and CPD-10 (HY-168660).
    Palbociclib-CH2COOH
  • HY-128837A
    (rel)-Nutlin carboxylic acid 2760669-71-2
    (rel)-Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel)-Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC.
    (rel)-Nutlin carboxylic acid
  • HY-179351
    EZH2 ligand-1 2641602-26-6
    EZH2 ligand-1 (Compound E) is an EZH2 ligand that can be used for the synthesis of PORTAC.
    EZH2 ligand-1
  • HY-175653
    Androgen receptor ligand 2 3056514-89-4
    Androgen receptor ligand 2 is a PROTAC target protein ligand that can be used to synthesize the PROTAC Androgen receptor degrader-1 (HY-175652).
    Androgen receptor ligand 2
  • HY-181501
    CDK2/4/6-IN-3
    CDK2/4/6-IN-3 (compound 32a) is a CDK2/4/6 inhibitor. CDK2/4/6-IN-3 can be used as a target protein ligand for the synthesis of PROTAC WWZ-11-098 (HY-181490).
    CDK2/4/6-IN-3
  • HY-179442
    AR ligand-48 1318208-88-6
    AR ligand-48 is an AR (Androgen Receptor) inhibitor and a ligand for the target protein for PROTAC (AR). AR ligand-48 can be used to synthesize PROTAC AR Degrader-12 (HY-179433).
    AR ligand-48
  • HY-158340
    TYK2 ligand 1 2770471-05-9
    TYK2 ligand 1 is a TYK2 ligand in the synthesis of PROTAC-based TYK2 degrader (CPD-155, HY-158142).
    TYK2 ligand 1
  • HY-185582
    EZH2 ligand-4 3050872-19-7
    EZH2 ligand-4 (Precursor 1) is a ligand for the target protein for PROTAC (EZH2). EZH2 ligand-4 can be used to synthesize MS8847 (HY-162250).
    EZH2 ligand-4